Dr. Teepu Siddique’s team discovers cause of ALS

August 25, 2011 by · 1 Comment 

communityCHICAGO,IL–Northwestern University researchers have discovered the cause of the Lou Gehrig’s disease (also known as ALS). The study’s lead author is Dr. Teepu Siddique, of Northwestern’s Feinberg School of Medicine and a neurologist at Northwestern Memorial hospital.

The study published in the prestigious Nature journal reveals that in the disease  the protein ubiquilin2 isn’t doing its job. As a result, the damaged proteins and ubiquilin2 loiter and accumulate in the motor neurons in the spinal cord and cortical and hippocampal neurons in the brain resembling twisted skeins of yarn and cause the degeneration of the neurons.

The researchers found ubiquilin2 in these skein-like accumulations in the spinal cords of ALS cases and in the brains of ALS/dementia cases.

Dr. Siddique has devoted his career as a clinician-scientist to the study and treatment of neuromuscular diseases, especially amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s Disease. He has directed the Neuromuscular Disorders Program/Neurogenetics Laboratory and the Les Turner ALS Foundation Laboratory at Northwestern since 1991.

Dr. Siddique led an international team that was the first to identify genes responsible for familial (inherited) forms of ALS: the SOD1 gene in 1993 and the ALS2, or alsin, gene in 2001. His laboratory also developed the first successful genetic mouse model of ALS in 1994. In 2008, his lab verified the existence of an X chromosome-linked gene (X-ALS) that may be involved in both ALS and ALS/dementia.

For his seminal work in ALS neurogenetics, Dr. Siddique received the first Sheila Essey Award from the American Academy of Neurology. Other honors include the Hope Through Caring Award from the Les Turner ALS Foundation, the Third Annual Eleanor and Lou Gehrig Award from the Columbia University College of Physician and Surgeons, and the Forbes Norris Award from the International Alliance of ALS/MND (Motor Neurone Disease) Associations.

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MJ Khan in Houston Controller Run-Off

November 7, 2009 by · Leave a Comment 

By Ilyas Hasan Choudry, MMNS

Houston—November 4–“It is a distinct honor for the Muslim, Pakistani and South Asian Communities that a competent person with right credentials, has qualified through Houstonians Votes, to the run-off elections of December 12th, 209 for the Controller Position of the fourth largest metropolis of USA.”

These were the sentiments of those gathered at the Campaign Headquarter of the termed-out City Councilman M. J. Khan located along Richmond Avenue just east of Hillcroft, as they celebrated the strong showing by M. J. on the actual voting day to come from behind into the second position behind the termed-out City Councilperson Ron Green and qualifying for the run-off on Saturday, December 12th, 2009. Early voting for Run-Offs is tentatively expected to be between November 30th and December 08th, 2009. M. J. Khan’s wife and son were also present on the occasion.

Khalid Khan, who was vying to replace M. J. Khan on the City Council Position “F”, came in a strong third place in a race of seven candidates. On the voting day of Tuesday, November 03, 2009, Khalid Khan was number two in the number of votes received, but Al Hoang got majority of his votes in the Early Voting.

When the early vote count came in around 7:00pm., M. J. Khan was third in the pack of three candidates for the Controller position, trailing the second place Pam Holm by about 1,300 votes. By the end of the evening, M. J. Khan had about 2,000 votes more than Pam Holm, who called into M. J. Khan Campaign Office to congratulate him for qualifying for the run-off.

In fact on the voting day of Tuesday, November 03, 2009, M. J. Khan received the most number of votes, as compared to Ron Green and Pam Holm, which according to analysts show that voters learned about M. J. Khan’s credentials late in the race through his TV advertisements and once the voters knew about his strong financial background, he got many votes. The same thing of educating voters through electronic media can help him win on December 12th, 2009 and for that M. J. will need good sum of donations from well-wishers and Houstonians.

This Controller race became most heated, when in the last few weeks to the elections, Ron Green admitted certain issues with liens on his properties by IRS and that these problems were much highlighted by his opponent Palm Holm, while M. J. Campaign stayed out from any negative comments.

M. J. Khan has created history by becoming the first ever Muslim, Pakistani and South Asian Candidate to be running in the run-off elections for the second biggest position of Controller of the 4th largest city of USA .

“I feel most humble that with the support of my community and right choice of the voters to elect a person with right credentials, I will be contesting in December 12th run-off. City of Houston is the best place to live and after having served the City for the past six years, I feel my qualifications are the most appropriate for the Controller position, so that I can contribute more towards the well-being of all Houstonians. I am grateful to each and everyone, who has voted for me and expect more voters to come out in the run-off and elect him to be the next City of Houston Controller because I have the right background and expertise to run the finances of this great city in the most amicable manner,” said M. J. Khan, as final results came in late around 11:45pm.

In other races, it will be mayoral election run-off as well. Here again all political pundits were proven wrong, when City Councilperson Peter Brown, even after spending more than $2-Million of his own and wife’s money, came in third. Since none of the candidates got 50%+, there will be run-off between top position Annise Parker and Gene Locke.

Here is how the final outcome of various campaigns was:

Houston Mayor – Annise Parker 54,193 (30.5%); Gene Locke 45,954 (25.90%); Peter Brown 39,904 (22.4%); Roy Morales 35925 (20.20%) (Run-Off);
Houston Controller – Number Of Votes Are For Harris County Only – Ronald C. Green 53,993 (36.3%); M. J. Khan 49,424 (32.5%); Pam Holm 47,701 (31.2%) (Run-Off);
City Council At-Large Pos. 1 – Stephen Costello 24.1%; Karen Derr 19.6% (Run-Off)
City Council At-Large Pos. 2 – Sue Lovell 48.8%; Andrew C. Burks Jr. 21.4% (Run-Off);
City Council At-Large Pos. 4 – C. O. Bradford Won 52.3%; Noel Freeman 21.1%;
City Council At-Large Pos. 5 – Jolanda “Jo” Jones (I) 42.1%; Jack Christie 36.4% (Run-Off);
City Council Dist. A – Brenda Stardig 31.9%; Lane Lewis 21.8% (Run-Off);
City Council Dist. B – Jarvis Johnson (I) Won 82.0%; Roger Bowden 18.0%;
City Council Dist. C – Anne Clutterbuck (I) Won 81.8%; Randolph Locke 17.5%;
City Council Dist. D – Wanda Adams Won 76.2%; Larry McKinzie 11.0%;
City Council Dist. E – Mike Sullivan (I) Won 74.1%; Wayne Garrison 25.9%;
City Council Dist. F – Mike Laster 2,436 (25.5%); Al Hoang 2,351 (24.6%); Khalid Khan 1,859 (19.5%) (Run-Off);
City Council Dist. G – Oliver Pennington Won 59.1%; Mills Worsham 17.8%.

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